TNF and inflammatory bowel disease: Pathway enrichment analysis was performed for the core targets, and a threshold value of less than P < .05 was set to obtain 134 signaling pathways, and the top 20 KEGG entries were ranked from smallest to largest P values for the graphs (Fig. 5), in which the signaling pathways associated with UC were mainly IL-17 signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, IBD, Th17 cell differentiation, and tumor-related pathways.