ESR1 and Behcet disease: The potential interaction target network of BD for treating UC and its core intersection target network of BD and UC were obtained using Cytoscape (3.9.0) and its plug-in (Fig. 3C), degree with there are 67 targets of BD active ingredients for the treatment of UC screened at a threshold greater than the median 45, among which targets greater than twice the degree are in a central position in BD for UC and may play important therapeutic roles, including IL-6, TNF, TP53, VEGFA, AKT1, IL-10, IL-1β, RELA, CASP3, MAPK1, JUN, EGFR, MYC, EGF FOS, ESR1, and PTGS2.