Using SNPs significantly associated with ALB, IVW analysis showed no significant causal association between ALB and CRC (OR = 1.04, 95% CI = 0.89–1.21, P = .65), MR-Egger (0R = 0.84, 95% CI = 0.63–1.14, P = .27), or weighted median (OR = 0.95, 95% CI = 0.75–1.20, P = .67) (Fig. 5). Here, ALB is linked to colorectal carcinoma.