ALB and neoplasm: TP is a hepatic metabolite,[11] and its decline is associated with reduced liver function, which has been shown to be associated with CRC.[29] TP is a common indicator used to evaluate nutritional status, which is associated with the development of CRC.[30] TP consists of several types of proteins, of which ALB and globulin are predominant; globulin includes α, β, and γ globulin; immunoglobulins belonging to the γ-globulin family can recognize and remove foreign molecules, and a decrease in globulin is detrimental to the removal of tumor components.