One study found no significant correlation between ALB and CRC.[13] Other studies proved that ALB showed a negative correlation with CRC.[11,14] One study showed a positive correlation between ALB and left-sided distal CRC.[15] Regarding the causal relationship between ALB and CRC, a previous study on East Asians confirmed a negative association between ALB and CRC.[9] To the best of our knowledge, there have been no studies on the causal relationship between ALB and CRC in Europeans. This evidence concerns the gene ALB and colorectal carcinoma.