SIRT1 and neoplasm: TP53, A tumor suppressor involved in ROS detoxification and apoptosis regulation.[32] IL6, Combines autophagy with antioxidant responses, mitigating oxidative stress in β-cells.[33,34] AKT1, Modulates cell survival and oxidative stress, influenced by SIRT1 overexpression.[35,36] STAT3, Regulates redox homeostasis by modulating antioxidant enzymes.[37] TNF, mediates oxidative stress-induced cell death.[38,39]