ITGAM and acute myeloid leukemia: ITGAM, encoding the integrin αM component of the Mac-1 complex (CD11b), is involved in leukocyte adhesion, migration, and phagocytosis in monocytes, macrophages, neutrophils, and dendritic cells.[52,53] It has been reported that ITGAM may serve as a promising prognostic biomarker and therapeutic target for AML.[54] Elevated ITGAM levels in AML are linked to poor survival outcomes.