Direct delivery of the JAGGED1 ligand has been shown to effectively facilitate fracture healing in a mouse model.[27] Besides, there are studies on inducing pluripotent stem cells by using CRISPR/Cas9 technology in human to correct mutations in other inherited diseases in vitro.[28] In general, these approaches are under investigation in animal models or in vitro, and have great potential as viable therapeutic interventions for ALGS. The gene discussed is JAG1; the disease is hereditary disease.