STAT3 and type 2 diabetes mellitus: Previous studies have indicated a significant role of PPARG and PPARG gene polymorphisms in the pathogenesis of type 2 diabetes[25]; STAT3 can regulate the expression of genes related to cell survival, proliferation, activation, and differentiation, and plays an important role in islet development and insulin secretion.[26] The chemical components of JAs may combine with PPARG, STAT3, and other targets, act on insulin synthesis and other processes, and play a role in lowering blood sugar.