PIM3 and Sepsis: Neutrophils play a critical role in the early phase of sepsis by phagocytosing and eliminating pathogens.[28] However, their excessive activation can lead to the release of reactive oxygen species, neutrophil extracellular traps, and proteases, which damage the endothelial barrier and trigger systemic inflammation.[29] In this study, elevated expression of SIGLEC5, PIM3, and NEDD4 was positively correlated with neutrophil infiltration, suggesting that these genes may facilitate neutrophil recruitment by regulating cytokines and chemokines.