Studies have found higher levels of plasminogen activator inhibitor-1 in female AIS patients, which is an independent predictor of thrombolysis resistance.[35] In addition to the aforementioned factors, our univariate analysis found significant differences in age, atrial fibrillation history, fibrinogen level, and systolic blood pressure between the effective and noneffective groups. This evidence concerns the gene SERPINE1 and atrial fibrillation.