In an obese state, blood exhibits a hypercoagulable tendency due to increased fibrinogen levels and enhanced platelet activity – thereby raising the risk of thrombosis.[60–63] Furthermore, obesity activates both the sympathetic nervous system and the renin-angiotensin-aldosterone system, resulting in elevated blood pressure and an augmented cardiovascular burden.[52] In summary, the mediating role of obesity between ADHD and CAD underscores its multifaceted pathological mechanisms. This evidence concerns the gene REN and obesity due to melanocortin 4 receptor deficiency.