TAGLN2 and pulmonary arterial hypertension: TAGLN2 is highly expressed in smooth muscle and epithelial cells and is also found in non-smooth muscle cells such as endothelial cells, bone marrow cells, and pancreatic cells.[20–23] Moreover, it is widely expressed across various tissues, including the lungs, ovaries, bladder, colon, spleen, and pancreas.[21,24,25] TAGLN2 is abnormally expressed in several cardiovascular and pulmonary diseases,[26–28] but its specific role in PAH remains underexplored.