Laboratory findings showed hypernatremia (Na 155.7–157.5 mmol/L), hyperchloremia (Cl 113.6–119.1 mmol/L), low TSH (0.015–0.144 μIU/mL) with low-to-normal FT3/FT4, persistently low cortisol, low FSH/LH, and low PRL. Here, PLOD1 is linked to Hyperchloremia.