In patients with malignant tumors and CI, mucinous tumor markers (such as CA125 and CA199) can induce hypercoagulation through bidirectional signaling between neutrophils and platelets, promoting tumor thrombus formation.[19] This is often accompanied by elevated D-dimer levels.[2] These markers are also commonly elevated in patients with adenomyosis, as observed in Patient 2 of this study and in previous reports. This evidence concerns the gene MUC16 and adenomyosis.