Continued medication cause downregulation of GnRH-α receptors and desensitization, thereby inhibiting gonadotropin secretion and inducing pharmacological menopause, which helps control abnormal endometrial hyperplasia and bleeding.[45] During treatment, calcium and vitamin D must be supplemented in advance, and bone status should be monitored to avoid irreversible osteoporosis.[46] Antithrombotic drugs can be selectively resumed 1 month after stabilization of pharmacological menopause. Here, GNRHR is linked to osteoporosis.