The IVW results showed a significant positive correlation between the risk of AP and Interleukin-15 receptor subunit alpha levels [OR = 1.128; 95% CI, 1.056–1.204; P = .000], Interleukin-1-alpha levels [OR = 1.115; 95% CI, 1.003–1.239; P = .044], Interleukin-2 receptor subunit beta levels [OR = 1.116; 95% CI, 1.005–1.240; P = .040], Monocyte chemoattractant protein-4 levels [OR = 1.117; 95% CI, 1.033–1.208; P = .006], and Tumor necrosis factor receptor superfamily member 9 levels [OR = 1.157; 95% CI, 1.051–1.273; P = .003]. The gene discussed is IL2RB; the disease is alkaline phosphatase measurement.