GPR176 and Anxiety: We analyzed animal behavior in an open filed arena and found that while knockdown of Gpr176 did not change the locomotor activity of mice (Fig. 6D; Total distance [cm]: Control, 6096 ± 292; sh-Gpr176, 5275 ± 359), the dwell time in the central area of the arena increased compared with the control (Fig. 6D; Time spent in central area [s]: Control, 159.0 ± 16.9; sh-Gpr176, 223.0 ± 13.3; Time spent in outer area [s]: Control, 443.0 ± 16.9; sh-Gpr176, 378.0 ± 13.3), suggesting decreased anxiety-like behavior.