MMP2 and airway hyperresponsiveness: Reports are showing contradictory roles of MMP-2 in the context of asthma, Takahashi et al. is showing that it has a protective role in terms of airway hyperresponsiveness, while Kuwabara and his colleagues showed that higher levels of MMP-2 is associated with elevated levels of myofibroblast migration to the airway thus enhancing fibrosis [25].