sFRP1 reinstates glycogen synthase kinase 3β (GSK3β) activity, thereby facilitating Rac1 activation, while ectopic overexpression of Rac1 concurrently suppresses SMAD family member 3 (Smad3) activity; these interactions collectively enhance the malignant phenotype of EMT in gastric cancer [82]. The gene discussed is SFRP1; the disease is gastric cancer.