Xu et al. discovered that the bioactive protein pPeOp (from Omphalia lapidescens) could reduce the expression and activation of Rac1 and Cdc42, along with their downstream targets (p-PI3K, p-AKT, AKT, p-PAK1, and RACGAP1), resulting in the disruption of cytoskeletal structure and the inhibition of gastric cancer cell proliferation, migration, and invasion [123]. This evidence concerns the gene CDC42 and gastric cancer.