In other cases, such as with the previously mentioned deletion of the 9p21 chromosomal region, both cell cycle regulators and actors of the tumour cell-autonomous innate immune response are altered, impairing effective immune surveillance [172, 247–249]: this specific genomic alteration has been linked to a “cold” TME, characterized by reduced immune cell infiltration and impaired response to anti-PD-(L)1 agents [247]. Here, CD274 is linked to neoplasm.