The resultant production of type I interferons and associated cytokines is traditionally known to enhance host immune surveillance [150, 151], acting as an alarm signal that rewires the tumour immune microenvironment to a more active state, via increased cytotoxic activity of CD8 + T-cells and NK cells against malignant cells, activation of dendritic cells, and enhanced presentation of tumour antigens to T-cells following MHC upregulation [152, 153]. This evidence concerns the gene CD8A and neoplasm.