Treatment with 10 μM M102 led to a significant increase in MN survival in co-cultures with 7 out of 9 different iAstrocyte patient lines, including SOD1, C9orf72 and sporadic ALS cases (Fig. 7C, two-way ANOVA followed by Šídák’s multiple comparisons test). This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.