SOD1 and amyotrophic lateral sclerosis: Consistent with these findings, iAstrocytes derived from SOD1, C9orf72 and sporadic ALS patients treated with 10 μM M102 for 48 h showed decreased levels of oxidised RNA, thus confirming that M102 is capable of reducing the levels of oxidative stress in ALS astrocytes (Fig. 6A, B, two-way ANOVA followed by Šídák’s multiple comparisons test).