Importantly, when treated with 10 μM of M102 for 48 h, the levels of NQO1 increase significantly in iAstrocytes from healthy controls and ALS patients, including SOD1, C9orf72 and sporadic patient lines (Fig. 5A, C, two-way ANOVA followed by Šídák’s multiple comparisons test). This evidence concerns the gene NQO1 and amyotrophic lateral sclerosis.