SP100 and cancer: Where SP100 is situated in an offensive position, it bioenergetically engages with PML and HP1 as a nuclear body, regulating chromatin compaction and transcriptionally repressing pro-oncogenic gene expression; thus, the diminished presence of SP100 upregulates pro-oncogenic NF-kB, RAS, and MYC superpathways, all of which facilitate transformation to cancer [5].