TIA1 and neurodegenerative disease: Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis revealed that these TIA1-associated proteins were enriched in processes related to cytoplasmic stress granule assembly, translation, RNA processing and RNA binding and are associated with neurodegenerative diseases (Appendix Fig. S2A; Dataset EV3), consistent with TIA1’s established functions (Del Gatto-Konczak et al, 2000; Gilks et al, 2004; Kedersha et al, 1999; López de Silanes et al, 2005; Piecyk et al, 2000; Yamasaki et al, 2007).