Mutations in the PrLD of TIA1 can cause the formation of insoluble (pathological) aggregates and are associated with several neurodegenerative diseases, including FTD and ALS (Mackenzie et al, 2017), and Welander distal myopathy (WDM) (Hackman et al, 2013). The gene discussed is TIA1; the disease is frontotemporal dementia.