Specifically, mutations in TIA1 have been linked to WDM (Hackman et al, 2013), FTD, and ALS (Gu et al, 2018; Mackenzie et al, 2017; Yuan et al, 2018), and multisystem proteinopathy (MSP) (Lee et al, 2018). This evidence concerns the gene TIA1 and amyotrophic lateral sclerosis.