Although the frequencies of CD73+ T cells are reduced across T cell subsets in HIV infection, CD73+CD8+ T cells exhibit both diminished cytokine production (including TNF-α, IFN-γ, and IL-2) and upregulated expression of homing receptors (CCR7 and α4β7 integrin), indicating that these cells possess enhanced migratory capacity [222]. This evidence concerns the gene NT5E and HIV infectious disease.