NT5E and neoplasm: CD73 limits the differentiation and metabolic fitness of CD8+ T cells through the action of eADO, while CD73 deficiency enhances the cytotoxic potential of these cells, characterized by increased production of IFN-γ, TNF-α, and granzyme B, as well as elevated glucose uptake and heightened mitochondrial respiration, resulting in improved tumor growth inhibition [73].