ESR1 and breast carcinoma: Each sheet, whether depicting ER + , TNBC, older, younger, differential, major cell types, or more granular cell subpopulations, also indicates the absolute sum of incoming and outgoing interaction strengths per cell type Clinical information for TMAs including patient ID, age at diagnosis, clinical cohort origin, and breast cancer subtype, and distance traits depicting the percentage of ECs within 30μm of CAFs, the percentage of CD8 + T cells within 30μm of CAFs, the percentage of CD8 + T cells within 30μm of tumor epithelial cells, and the study cohort.