Adhesion-related signaling nodes were both age-dependent and cell-type-specific; nearly all adhesion/ECM signaling nodes involving either cancer luminal A cells, differentiated PVLs or macrophages were enriched in the older cohort, while those involving iCAFs, myCAFs and ACKR1+ ECs were mostly enriched in the younger cohort (Fig. 6b). This evidence concerns the gene ACKR1 and cancer.