HLA-F and cancer: Immunosuppressive signaling nodes40,41 between the MHC class I molecule, HLA-F, on both cancer basal cells and CAFs and the inhibitory receptor, leukocyte immunoglobulin like receptor B1 (LILRB1), on monocyte/macrophages, were also noted in older patients (Fig. 6a and Supplementary Fig. 4).