The result was emergent rescue: in particular, Wnt pathway inhibitors PNU-74654 (Trosset et al, 2006) and LF3 (Fang et al, 2016)—which act by suppressing the interaction between β-Catenin and TCF—demonstrated strong efficacy in reducing RAP tumours when paired with trametinib (Fig. 4B,C). This evidence concerns the gene HNF4A and neoplasm.