In this study, we conduct an in-depth analysis of ‘RAP’ tumours that contain the three genes most commonly mutated in human CRC: RAS (typically KRAS), APC, and P53. We found that pairing oncogenic RasG12V with elevated Wnt activity led to upregulation of canonical NF-κB signalling, both in Drosophila hindgut tumours and human tumours. Here, TP53 is linked to colorectal carcinoma.