We found that elevated WNT (Wg in Drosophila) activity led to upregulation of canonical nuclear factor-kappa B (NF-κB) signalling in RasG12V tumours, which in turn led to emergent resistance to drugs such as the MEK inhibitor trametinib by elevating glucuronidation pathway activity. The gene discussed is NFKB1; the disease is neoplasm.