To further clarify the relationship between Prkci and c-Myc in colorectal cancer cell proliferation, we used the cell line from Fig. 5I to construct four kinds of LoVo cells stably expressing vector + c-Myc WT, Prkci + c-Myc WT, vector + c-Myc S21A, Prkci + c-Myc S21A, respectively. Here, MYC is linked to colorectal cancer.