Our study identified significant locus-specific correlations between DNA methylation and expression of CDKN1A, KLF2, and IFNG. These methylation-regulated transcriptional networks functionally augment our CDKN1A/KLF2/IFNG-integrated risk stratification framework, enhancing prognostic precision in high-risk DLBCL. The gene discussed is IFNG; the disease is diffuse large B-cell lymphoma.