IFNG, a crucial cytokine for macrophage activation and antigen presentation facilitation32, defines a distinct subtype of hematologic malignancies characterized by immune infiltration and poor chemotherapy outcomes33.Beyond its established immunoregulatory roles, IFNG also regulates ferroptosis in cancer cells through inhibition of glutathione synthesis34,35, revealing a targetable mechanism for cancer immunotherapy. This evidence concerns the gene IFNG and cancer.