Thus, in the present preregistered study we investigated (a) how longitudinal changes in FC within and between MTL and PMC regions are related to AD pathology and the APOE4 genotype in the aging brain, (b) how these changes are related to changes in episodic memory performance, and (c) whether similar changes in FC occur during resting-state and episodic memory task fMRI. This evidence concerns the gene APOE and Alzheimer disease.