Our study established a diagnostic model for endometriosis consisting of four endoplasmic reticulum stress-related genes, which are VWF, F8, EPAS1, and VCAM1.VWF is often regarded as a marker of vascular endothelial damage, and endoplasmic reticulum stress levels were increased in a mouse model of systemic lupus erythematosus-associated diffuse alveolar hemorrhage (DAH) along with the levels of VWF, suggesting that VWF may be a target of endoplasmic reticulum stress leading to vascular endothelial dysfunction-associated diseases19. The gene discussed is EPAS1; the disease is endometriosis.