TRAF6 and infection: We also conducted the GSEA analysis, the results showed that role of mammalian E proteins E2A and HEB in the development of T cells and N-ras in T cell development and function were significantly enriched in ERS cluster B (Fig. 9g), while functions TRAF6 regulated CD8 T cell memory development following infection by modulating fatty acid metabolism, extrathymic Treg development and STAT6 down-regulated in bone marrow-derived macrophages were significantly enriched in cluster A (Fig. 9h).