Notably, we found that “MULTI CANCER INVASIVENESS” gene signature was markedly enriched in the CRC tumors with LNM compared to LMN-negative samples in the GSEA (Fig. 2F and Supplementary Fig. S2B), suggesting that unique transcriptome changes responsible for CRC progression and metastasis are highly enriched in LMN-positive compared to LMN-negative tumors. The gene discussed is LMNB1; the disease is colorectal carcinoma.