Given that genetic knockdown (KD) and chemical inhibition (AYNE) of VLCAD promoted cell death in AML cells [18], we anticipated that ART inhibits the VLCAD enzymatic activity, as evidenced by the direct interaction from the chemical drug proteomics (Fig. 2c) and accumulation of C16 palmitoyl carnitine from our metabolomics data (Fig. 2d). This evidence concerns the gene ACADVL and acute myeloid leukemia.