Local genetic correlations with LAVA28 (Fig. 6b, Supplementary Data 17) showed 5 negative local genetic correlations between area of the genu and neuroticism on the 17q21.31 cytogenetic band (STH, KANSL1, SPPL2C, CRHR1, and MAPT), and 9 positive local genetic correlations between anterior body area and Parkinson’s disease (PD) on the 17q21.31 cytogenetic band (MAPT, SPPL2C, STH, CRHR1, ARHGAP27, KANSL1, PLEKHM1, MAP3K14 and DCAKD). Here, SPPL2C is linked to Parkinson disease.