C5AR1 and Sepsis: Sepsis is often associated with consumptive coagulopathy, indicating a loss of control of the clotting and fibrinolytic systems, such as elevated PT (prothrombin time) or APTT (activated partial thromboplastin time), prolonged TT (thrombin time) and decreased Fbg (fibrinogen).22 Targeted blockade of C5a would provide dual therapeutic benefits—simultaneously suppressing excessive inflammation and mitigating coagulation dysfunction in sepsis.