FANCA and Friedreich ataxia: To explore potential autophagy deficiencies in the context of the FA pathway, we assessed mTORC1 activation by quantifying the levels phosphorylated 4E-BP1 (p4E-BP1) and found an increase in p4E-BP1 in FA mutants (FaDu FANCA/D2-null) compared to WT (Supplementary Fig. S21).