TP53 and neoplasm: The gene with the highest \documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{upgreek}\usepackage{mathrsfs}\setlength{\oddsidemargin}{-69pt}\begin{document}${\rho }_{\textit{case}}$\end{document}, CCDC8 (Fig. 7A, Table 1), encodes a cofactor required for p53-mediated apoptosis [30] whose downregulation is an unfavorable prognostic biomarker [31] and whose knockdown directly promotes tumor growth [32].