TARDBP and amyotrophic lateral sclerosis: In ALS/FTD postmortem tissue, stress-induced nucleolar changes occur upstream of TDP-43 pathology (Haeusler et al, 2014; Mizielinska et al, 2017; Aladesuyi Arogundade et al, 2021), supporting a model for increased crosstalk between nucleolar proteins and TDP-43 in the propagation of disease.