Prostate cancer exhibits even more pronounced racial variations: Black men show higher frequencies of SPOP and ZFHX3 mutations but lower rates of TMPRSS2‐ERG fusions and PTEN deletions compared to White men [24, 25], while Asian men demonstrate increased FOXA1 mutations and fewer PTEN alterations [26, 27]. This evidence concerns the gene SPOP and Familial prostate cancer.