In the CAD risk factor model, generated through binary logistic regression analysis and adjusted for confounding variables (including dyslipidemia, defined as total cholesterol ≥200 mg/dL, LDL-C ≥130 mg/dL, triglycerides ≥150 mg/dL, HDL-C <40 mg/dL or the use of lipid-lowering therapy; hypertension; age; smoking; and fasting glucose levels), irisin did not maintain statistical significance as an independent predictor. This evidence concerns the gene FNDC5 and hypertensive disorder.