In support of this conclusion, chronic inflammatory diseases such as atherosclerosis and type 2 diabetes (Ming et al., 2012), inflammaging in lung (Zhu et al., 2023), kidney (Huang et al., 2021), and pancreas (Xiong et al., 2017b) of aged animals or acute organ injury such as acute ischemic/reperfusion or cisplatin-induced renal injury are reduced in the Arg2-/- mice (Uchida et al., 2023). This evidence concerns the gene ARG2 and atherosclerosis.