PRPF31 and glioblastoma: To further explore PKCα functional roles for PKCα or the PKCα-D463H mutant in glioblastoma biology, STRING (19) analysis was conducted on proteins showing preferential binding to D463H over WT, which revealed networking between epigenetic regulators, including BRD4 and the MLL1 complex components HCFC1 (HCF-1) and PRPF31 (Fig. 4E).