In summary, our study identified five key genes (HNRNPC, PLK1, PRC1, RCC1, and UBA52) and their upstream miRNAs (miR-124-3p, miR-133a-3p, and miR-17-5p) through bioinformatics analysis, which play important roles in cell cycle regulation, signal transduction, and PCa identification. This evidence concerns the gene PLK1 and posterior cortical atrophy.