We selected and then evaluated three upregulated genes (HNRNPC, PLK1, and RCC1) and two downregulated genes (PRC1, UBA52) that were among the core genes associated with PCa, along with their upstream miRNAs, including miR-124-3p, miR-133a-3p, and miR-17-5p. The gene discussed is PLK1; the disease is posterior cortical atrophy.