To delve into the mechanism by which TIMP1 regulates Tregs in epithelial cells of the tumor group, we categorized the epithelial cells in the tumor group into TIMP1-positive epithelial cell (TIMP1+Epi) and TIMP1-negative epithelial cell (TIMP1-Epi) subsets based on TIMP1 expression. This evidence concerns the gene TIMP1 and neoplasm.