However, Zhang et al. challenged these findings, citing the absence of a correlation between plasma renin and C3 levels in patients with C3 glomerulopathy (C3G) or atypical hemolytic uremic syndrome (aHUS), and demonstrating that recombinant renin did not cleave C3 in vitro [30]. This evidence concerns the gene C3 and atypical hemolytic-uremic syndrome.