S1PR1 and hepatocellular carcinoma: In human Huh7 and SMMC-7721 hepatocytes cell lines, lncRNA KCNQ1OT1 can promote S1PR1 expression by sponging miR-149, which can downregulate S1PR1expression by targeting the 30-UTR of S1PR1 mRNA, which then facilitate the progress of HCC [37].