A number of studies have confirmed that a variety of lncRNAs such as AC005332.5, ELF3–AS1, LINC00665, PCAT6, HULC, HOTAIR and LINC00152 are abnormally expressed in HCC, which is closely related to the occurrence, development and prognosis of tumors. The gene discussed is HOTAIR; the disease is hepatocellular carcinoma.