The Wnt, PTEN and PI3K/AKT pathways have all been implicated in TNBC growth, progression and metastasis [18] miRNAs have considerable therapeutic potential and have been identified as oncogene suppressors, tumor suppressors and signaling molecules [19–21].However, roles of RANBP1 and underlying molecular mechanisms remain unclear although this protein may have therapeutic potential via its impact on miRNA synthesis. This evidence concerns the gene PTEN and neoplasm.