Logistic regression analysis demonstrated a significant effect of dose (P < 0.0001) and genotype (P = 0.05) on prion disease diagnosis, with infected Stx6+/+ mice having 2.19 [95% CI 1.01–4.56] times higher odds of developing prion disease compared to Stx6−/− animals at concentrations 10–5 and lower. The gene discussed is STX6; the disease is prion disease.