Further, the expression survival analysis found MYC and STAT3 in BC, CTNNB1 in PC, JUN, and BRCA1 in OC, and ESR1 in EC were significantly dysregulated and further mutational profiling validated MYC with 18%, STAT3 with 2.6%, and all other genes with 4% mutation. The gene discussed is ESR1; the disease is breast cancer.