According to some data, specific genetic loci influence craniofacial development and enamel formation, potentially affecting caries susceptibility.33 For example, studies have suggested that variants in AMELX, ENAM, and DSPP genes, which regulate enamel and dentin formation, may contribute to malocclusion and caries risk.23 In this study, data on caries were collected from 3 large cohorts. This evidence concerns the gene ENAM and Dental malocclusion.