HAVCR2 and cancer: The overexpression of TIM‐3 may be considered as a cancer biomarker, correlating with a bad prognosis,[40, 41, 42] while the blockade of TIM‐3 activity has shown beneficial effects, even for the treatment of tumors in advanced stages.[43, 44, 45] Structurally the IgV domain of TIM‐3 is composed of a rigid core, rich in β‐barrel motifs, flanked by four flexible loops.