Importantly, the increased efferocytosis efficiency in the macrophage-TRIB3 deficient mice was associated with an increase in expression of Rab27 in lesional macrophages, suggesting that the ATF4/TRIB3/Rab27 axis that we discovered using in vitro studies is relevant and operative in vivo in the context of advanced atherosclerosis. Here, ATF4 is linked to atherosclerosis.