TRIB3 and atherosclerosis: However, nondiabetic people with the Q84R variant also demonstrate enhanced adverse CAD outcomes suggesting that TRIB3 could accelerate atherosclerosis progression independent of its metabolic effects.57 Interestingly, our data reveal that relative to macrophages from individuals with the TRIB3 Q84, those with the 84R variant contain more TRIB3 and, these have a lower efferocytosis efficiency.