For example, the rs1576625 T allele (upstream gene variant 17,262 base pairs away from EDA2R) is associated with increased EDA2R expression in cultured fibroblasts (p = 0.0015) and skin (p = 0.0074), as well as with elevated risks of advanced (stage IV) male pattern baldness (p = 6.5 × 10−86), facial ageing (p = 7.3 × 10−7) and prostate cancer (p = 6.3 × 10−6) in the UK Biobank cohort (Open Targets Platform 2025), suggesting that elevated EDA2R expression may be an unfavourable trait linked to age‐related and pathological conditions. This evidence concerns the gene EDA2R and Familial prostate cancer.