Furthermore, EDA2R transcript levels were significantly elevated in skeletal muscle biopsies from patients with cachectic lung, colorectal, pancreatic and upper gastrointestinal cancers, as well as in those with Duchenne muscular dystrophy (DMD) and facioscapulohumeral muscular dystrophy (FSHD), conditions characterised by pronounced muscle mass and function loss (Bilgic et al. 2023). This evidence concerns the gene EDA2R and facioscapulohumeral muscular dystrophy.