EDA2R and prostate cancer: For example, the rs1576625 T allele (upstream gene variant 17,262 base pairs away from EDA2R) is associated with increased EDA2R expression in cultured fibroblasts (p = 0.0015) and skin (p = 0.0074), as well as with elevated risks of advanced (stage IV) male pattern baldness (p = 6.5 × 10−86), facial ageing (p = 7.3 × 10−7) and prostate cancer (p = 6.3 × 10−6) in the UK Biobank cohort (Open Targets Platform 2025), suggesting that elevated EDA2R expression may be an unfavourable trait linked to age‐related and pathological conditions.