Comparisons of blood and synovial biomarkers further revealed higher serum C-reactive protein (CRP), erythrocyte sedimentation rate, and D-dimer in PJI, along with higher synovial white blood cell (WBC) count, polymorphonuclear neutrophil (PMN) percentage, and alpha-defensin (Figs. 1-B and 1-C). The gene discussed is CRP; the disease is juvenile polyposis syndrome.